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KMID : 0895820130230030045
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 3 p.45 ~ p.53
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Effects of Ojeoksangamibang Extract on the Recovery of Liver Function in CCl4-exposed Rats
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Lee Soo-Yeon
Park Won-Hyung
Cha Yun-Yeop
Lee Eun
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Abstract
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Objectives : The objective of present study was to investigate the effect of Ojeoksangamibang (Wujisanjiaweifang) extract on recovery of liver function in carbontetrachloride (CCl4)-exposed rat.
Methods : Male rats weighing 230±7.21 g fed experimental diet for 1 week and 28 rats were divided into 4 groups. Each of 7 rats was devided into a control group and experimental groups. We fed a control group of rats a basal diet and administered normal saline (100 mg/kg, 1 time/1 day) for 3 weeks. And we fed each experimental group of rats basal diet and administered an extract of Ojeoksangamibang extracts (100 mg/kg, 200 mg/kg, 300 mg/kg, 1 time/1 day) for 3 weeks. We measured lipid of plasma and liver, concentration of proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-10). Statistical analysis was done by one-way analysis of variance (ANOVA) and Duncan`s multiple range test with significance level at p＜0.05.
Results : Plasma a-fetoprotein (AFP) and total protein concentration showed a tendency to decrease in Ojeoksangamibang extract-treated groups. However, plasma albumin concentration showed no significant differences in all treatment groups. Activity of plasma Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) in the Ojeoksangamibang extract-treated groups, increased addition amount of Ojeoksangamibang extracts tended to decline. Alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-glutamyl transferase (γ-GT) activities showed a tendency to decrease in Ojeoksangamibang extract-treated groups, increased addition amount of Ojeoksangamibang extracts tended to decline. Concentration of plasma triglyceride and total cholesterol showed a lower value than that of control group. The liver IL-1β, IL-6 and TNF-α concentration were decreased, and IL-10 was increased in Ojeoksangamibang extract groups, compared to control group. Plasma IL-1β, IL-6 and TNF-α concentration were decreased, and IL-10 was increased in Ojeoksangamibang extract groups, compared to control group.
Conclusions : This study suggested that Ojeoksangamibang may alleviate liver inflammatory reaction induced by liver toxicity.
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KEYWORD
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Ojeoksangamibang extract, Liver function, A-fetoprotein, AST, ALT, Cytokines
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